Department of Obstetrics and Gynecology, Pamukkale University School of Medicine, Denizli, Turkey,
Arch Gynecol Obstet. 2014 Aug;290(2):249-56. doi: 10.1007/s00404-014-3201-0. Epub 2014 Mar 19.
To investigate the efficacy of bupivacaine-soaked spongostan in cesarean section wound for postoperative anxiety level, satisfaction and early postpartum depression rate.
A total of 121 women, American Society of Anesthesiologists physical status I-II, scheduled to undergo general anesthesia and elective cesarean section were recruited and randomized into a study group (n = 61) or a control group (n = 60). In the spongostan group, bupivacaine-soaked spongostan was placed in the cesarean section wound. The control group did not receive spongostan, but only general postoperative care. Maternal health was assessed using a visual analog scale for satisfaction, a visual analog scale for anxiety and the Edinburgh Postpartum Depression Scale for postpartum depression. Also, first breast-feeding time, first mobilization time and opioid consumption were recorded and compared.
The anxiety level of the spongostan group was lower than that of the control group and the difference was statistically significant at all time intervals (1, 6, 12, 18, 24, 30, 36 and 48 h, p < 0.001, respectively). Postpartum depression rate again was significantly lower in the spongostan group both on postoperative day 2 and day 9 (p ≤ 0.01). All satisfaction scores were significantly higher in the spongostan group than in the control group (p < 0.001). Additionally, first breast-feeding and first mobilization times were significantly shorter and opioid consumption was lower in the spongostan group (p < 0.001).
Placement of bupivacaine-soaked spongostan into the cesarean section wound resulted in decreased postoperative anxiety level and postpartum depression rate and increased satisfaction.
研究布比卡因浸渍的 Spongostan 在剖宫产伤口中的疗效，以观察其对术后焦虑水平、满意度和早期产后抑郁发生率的影响。
选择美国麻醉医师协会（ASA）身体状况 I-II 级、拟行全身麻醉和择期剖宫产的 121 例产妇，随机分为研究组（n=61）和对照组（n=60）。在 Spongostan 组，将布比卡因浸渍的 Spongostan 放置在剖宫产伤口中。对照组未放置 Spongostan，仅给予常规术后护理。采用视觉模拟评分法（VAS）评估满意度，VAS 焦虑评分评估焦虑水平，爱丁堡产后抑郁量表（EPDS）评估产后抑郁。记录并比较首次母乳喂养时间、首次活动时间和阿片类药物消耗量。
Spongostan 组的焦虑水平低于对照组，在所有时间点（1、6、12、18、24、30、36 和 48 h）差异均有统计学意义（p<0.001）。Spongostan 组产后抑郁发生率在第 2 天和第 9 天均显著低于对照组（p≤0.01）。Spongostan 组的所有满意度评分均明显高于对照组（p<0.001）。此外，Spongostan 组首次母乳喂养和首次活动时间明显缩短，阿片类药物消耗量较低（p<0.001）。
在剖宫产伤口中放置布比卡因浸渍的 Spongostan 可降低术后焦虑水平和产后抑郁发生率，提高满意度。
