阿昔洛韦对大鼠睾丸组织的毒性作用。
Toxic effect of acyclovir on testicular tissue in rats.
作者信息
Movahed Elham, Nejati Vahid, Sadrkhanlou Rajabali, Ahmadi Abbas
机构信息
Departmant of Biology, Faculty of Basic Sciences, Urmia University, Urmia, Iran.
Laboratory of Embryology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
出版信息
Iran J Reprod Med. 2013 Feb;11(2):111-8.
BACKGROUND
Acyclovir (ACV), a synthetic purine nucleoside analogue, is known to be toxic to gonads.
OBJECTIVE
The current study evaluated cytotoxicity of ACV on histopathological changes in testis tissue and serum testosterone and lipid peroxidation concentrations of male rats.
MATERIALS AND METHODS
Animals were divided into five groups. One group served as control and one group served as control sham. In the drug treated groups ACV administered for 15 days. 18 days after the last injection, animals were sacrificed. Histopathological and histomorphometrical analysis of the testis was carried out. Serum levels of testosterone and Lipid Peroxidation and potential fertility of animals was evaluated.
RESULTS
Male rats exposed to ACV had significant reduction in serum testosterone concentrations at 16 and 48mg/kg dose-levels (p<0.01). ACV induced histopathological changes in the testis and also increase the mean number of mast cells in peritubular or interstitial tissue in the testis at at 16 and 48mg/kg dose-levels (p<0.01). In addition ACV caused increase of serum level of Lipid Peroxidation at 48mg/kg dose-level (p<0.05). As well ACV decreased potential fertility in male rats.
CONCLUSION
The present results highly support the idea that ACV has adverse effect on the reproductive system in male rat.
背景
阿昔洛韦（ACV）是一种合成嘌呤核苷类似物，已知对性腺有毒性。
目的
本研究评估了阿昔洛韦对雄性大鼠睾丸组织组织病理学变化、血清睾酮以及脂质过氧化浓度的细胞毒性。
材料与方法
将动物分为五组。一组作为对照组，一组作为对照假手术组。在药物治疗组中，阿昔洛韦给药15天。最后一次注射后18天，处死动物。对睾丸进行组织病理学和组织形态计量学分析。评估动物血清睾酮水平、脂质过氧化水平以及潜在生育能力。
结果
暴露于阿昔洛韦的雄性大鼠在16和48mg/kg剂量水平时血清睾酮浓度显著降低（p<0.01）。阿昔洛韦在16和48mg/kg剂量水平时可诱导睾丸组织病理学变化，并增加睾丸曲管周围或间质组织中肥大细胞的平均数量（p<0.01）。此外，阿昔洛韦在48mg/kg剂量水平时导致血清脂质过氧化水平升高（p<0.05）。阿昔洛韦还降低了雄性大鼠的潜在生育能力。
结论
目前的结果有力地支持了阿昔洛韦对雄性大鼠生殖系统有不良影响这一观点。
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