胰岛素受体基因及脂联素基因多态性与多囊卵巢综合征的关系。
Relationship between polymorphism of insulin receptor gene, and adiponectin gene with PCOS.
作者信息
Ramezani Tehrani Fahimeh, Daneshpour Maryam, Hashemi Somayeh, Zarkesh Maryam, Azizi Feridoun
机构信息
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Reprod Med. 2013 Mar;11(3):185-94.
BACKGROUND
Polycystic ovary syndrome (PCOS) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulin metabolism have been hypothesized to be involved in its etiology.
OBJECTIVE
We examined the possible association of adiponectin and insulin receptor gene polymorphisms with PCOS.
MATERIALS AND METHODS
A total of 186 women with PCOS using NIH criteria and 156 healthy women were recruited. Their samples were genotyped for the polymorphism in exon 17 and 8 of the insulin receptor gene or exon and intron 2 of the adiponectin gene.
RESULTS
The distributions of genotypes and alleles of both polymorphisms were not different in women with PCOS and controls. There was no significant differences on the anthropometric and hormonal profiles of various adiponectin and insulin receptor genes polymorphisms among both groups.
CONCLUSION
Adiponectin and insulin receptor gene polymorphisms are not associated with PCOS in a sample of Iranian population.
背景
多囊卵巢综合征（PCOS）是一种具有遗传和环境因素的复杂疾病，肥胖和胰岛素代谢相关的候选基因被认为参与了其病因。
目的
我们研究脂联素和胰岛素受体基因多态性与PCOS之间的可能关联。
材料与方法
共招募了186名符合美国国立卫生研究院（NIH）标准的PCOS女性和156名健康女性。对她们的样本进行胰岛素受体基因第17外显子和第8外显子或脂联素基因第2外显子和内含子多态性的基因分型。
结果
两种多态性的基因型和等位基因分布在PCOS女性和对照组中无差异。两组中各种脂联素和胰岛素受体基因多态性的人体测量和激素谱无显著差异。
结论
在伊朗人群样本中，脂联素和胰岛素受体基因多态性与PCOS无关。
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