Mohammed Yassin Maged, Akram Sharif Fadel, Marwan Laqqan Mohammed
Department of Physiology, Faculty of Medicine, The Islamic University of Gaza, Gaza Strip, Palestine.
Department of Molecular Biology, Faculty of Sciences, The Islamic University of Gaza, Gaza Strip, Palestine.
Iran J Reprod Med. 2013 Apr;11(4):261-6.
Back ground: Careful evaluation of patients and proper treatment with right techniques are essential for successful outcome of assisted reproduction. To obtain satisfactory results, it is necessary to assess ovarian reserve before planning treatment.
To evaluate anti-mullerian hormone as a predictor of fertility potential in terms of ovarian reserve and ovarian response reflected by antral follicles and mature oocyte counts in response to menotrophin stimulation in in vitro fertilization (IVF) women from Gaza Strip.
This prospective cohort study consisted of 81 women (mean age 28.7 years) attending IVF at Al-Basma Fertility Center in Gaza City. Blood withdrawal for antimullerian hormone measurement was performed in all the patients and the number of oocytes and embryos were recorded.
The total number of retrieved oocytes was inversely associated with age (12.5±4.5, 11.0±5.4 and 6.9±4.7 at age ≤25, 26-35 and >35 years, respectively (F=4.793 and p=0.011). The ovarian response to Menotrophin (FSH 75IU, LH 75 IU) stimulation was better for younger age. There was a significant positive association between ovarian response in terms of total number of oocytes and antimullerian hormone levels. The maximum level of antimullerian hormone was observed in females who achieved positive pregnancies (4.5±2.5 ng/mL) followed by negative pregnancies (2.9±1.8 ng/mL) with significant differences (F=6.862 and p=0.002). Correlation coefficient revealed that the number of mature oocytes showed strong positive correlation with the antimullerian hormone levels (r=0.469, p=0.001).
Anti-mullerian hormone can be used in IVF programs as a good predictor of ovarian reserve and ovarian response.
背景：对患者进行仔细评估并采用正确技术进行适当治疗对于辅助生殖的成功结果至关重要。为了获得满意的结果，在规划治疗前评估卵巢储备是必要的。
在加沙地带接受体外受精（IVF）的女性中，根据卵巢储备以及通过促卵泡生成素刺激后窦卵泡和成熟卵母细胞计数所反映的卵巢反应，评估抗苗勒管激素作为生育潜力预测指标的情况。
这项前瞻性队列研究包括81名在加沙城阿尔巴斯马生育中心接受IVF的女性（平均年龄28.7岁）。对所有患者进行采血以测量抗苗勒管激素，并记录卵母细胞和胚胎数量。
回收的卵母细胞总数与年龄呈负相关（年龄≤25岁、26 - 35岁和>35岁时分别为12.5±4.5、11.0±5.4和6.9±4.7，F = 4.793，p = 0.011）。年龄较小者对促卵泡生成素（FSH 75IU，LH 75 IU）刺激的卵巢反应更好。卵母细胞总数所反映的卵巢反应与抗苗勒管激素水平之间存在显著正相关。在成功妊娠的女性中观察到抗苗勒管激素的最高水平（4.5±2.5 ng/mL），其次是未妊娠女性（2.9±1.8 ng/mL），差异有统计学意义（F = 6.862，p = 0.002）。相关系数显示成熟卵母细胞数量与抗苗勒管激素水平呈强正相关（r = 0.469，p = 0.001）。
抗苗勒管激素可在IVF程序中用作卵巢储备和卵巢反应的良好预测指标。
