Ageevets V A, Partina I V, Lisitsina E S, Batyrshin I M, Popenko L N, Shliapnikov S A, Il'ina E N, Sidorenko S V
Antibiot Khimioter. 2013;58(3-4):10-3.
The study involved 25 isolates of gramnegative carbapenemase-producing bacteria. 17 isolates of Klebsiella pneumonia produced carbapenemase NDM-1 and were highly resistant to cephalosporins (MIC>128 mcg/ml), carbapenems (MIC>16 mcg/ml), aminoglycosides and fluoroquinoiones, while among them 4 isolates preserved susceptibility to azthreonam and all of them were susceptible to tigecycline and polymyxin. 2 isolates of Acinetobacter genomospecies 13 produced NDM-1 and were resistant to all the beta-lactams and amikacin, while preserved susceptibility to gentamicin, co-trimoxazole, tigecycline and polymyxin, the susceptibility to ciprofloxacin being lowered. Carbapenemase VIM-4 was produced by 2 isolates of Enterobacter cloacae, which were highly resistant to cephalosporins and azthreonam, significant synergism being observed between cefepim and clavulanate. The resistance of the isolates to carbapenems was low (MIC 0.5-4.0 mcg/ml), they also being resistant to aminoglycosides and ciprofioxacin and susceptible to tigecycline and polymyxin. Carbapenemases KPC-2 were detected in 2 isolates of K.pneumoniae and in 1 isolate of E.cloacae. The above isolates were resistant to all the beta-lactams, ciprofloxacin, aminoglycosides and co-trimoxazole. I isolate of E.cloacae showed resistance to tigecychine and I isolate of K.pneumoniae was resistant to polymyxin. Carbapenemase OXA-48 was detected in 1 isolate of K.pneumoniae. It was resistant to all the beta-lactams, ciprofloxacin and co-trimoxazole and susceptible to aminoglycosides, tigecycline and polymyxin.
该研究涉及25株产碳青霉烯酶革兰阴性菌。17株肺炎克雷伯菌产碳青霉烯酶NDM-1，对头孢菌素（MIC>128 mcg/ml）、碳青霉烯类（MIC>16 mcg/ml）、氨基糖苷类和氟喹诺酮类高度耐药，其中4株对氨曲南仍敏感，所有菌株对替加环素和多粘菌素敏感。2株基因组种13不动杆菌产NDM-1，对所有β-内酰胺类和阿米卡星耐药，但对庆大霉素、复方新诺明、替加环素和多粘菌素敏感，对环丙沙星的敏感性降低。2株阴沟肠杆菌产碳青霉烯酶VIM-4，对头孢菌素和氨曲南高度耐药，头孢吡肟与克拉维酸之间存在显著协同作用。这些菌株对碳青霉烯类的耐药性较低（MIC 0.5-4.0 mcg/ml），对氨基糖苷类和环丙沙星也耐药，对替加环素和多粘菌素敏感。在2株肺炎克雷伯菌和1株阴沟肠杆菌中检测到碳青霉烯酶KPC-2。上述菌株对所有β-内酰胺类、环丙沙星、氨基糖苷类和复方新诺明耐药。1株阴沟肠杆菌对替加环素耐药，1株肺炎克雷伯菌对多粘菌素耐药。在1株肺炎克雷伯菌中检测到碳青霉烯酶OXA-48。它对所有β-内酰胺类、环丙沙星和复方新诺明耐药，对氨基糖苷类、替加环素和多粘菌素敏感。
