Christiane Y, Emonard V, Emonard H
Rev Med Liege. 2014 Jan;69(1):46-50.
Matrix metalloproteinases, which remodel the extracellular matrix, are involved in all physiological and pathophysiological processes. In particular, they contribute to the success of a pregnancy: from embryo implantation in the endometrium to uterine cervical ripening and uterine involution. A misregulation of their expression and/or of their activity is observed in two major diseases in pregnancy such as spontaneous abortion and preeclampsia.
基质金属蛋白酶可重塑细胞外基质,参与所有生理和病理生理过程。特别是,它们对妊娠成功起着重要作用:从胚胎植入子宫内膜到宫颈成熟和子宫复旧。在妊娠的两种主要疾病如自然流产和子痫前期中,可观察到它们的表达和/或活性失调。