Torgashov M N, Miakotnykh V S, Pal'tsev A I
Adv Gerontol. 2013;26(3):525-32.
The peculiarities of violations of lipid metabolism and symptoms of post-traumatic stress disorder (PTSD) in 161 patients of 25-69 years, veterans of the military actions on the territory of Afghanistan and the Northern Caucasus were investigated. The dependence of the formation of dyslipidemia and related changes of atherosclerosis in the young age on neuroendocrine effects, accompanying the effects of combat stress and promoting accelerated aging was determined. On the other hand, with the time, after 15-25 years after participating in hostilities, the intensity of PTSD and its influence on the development of violations of lipid spectrum may decline. The leading role in the pathogenesis of dyslipidemia goes to age-related changes, accompanying a process of accelerated aging of veterans of combat operations, and to pathological disorders of metabolism in liver associated with alcohol abuse and the consequences of infectious diseases.
对161名年龄在25至69岁之间、曾参与阿富汗和北高加索地区军事行动的退伍军人的脂质代谢紊乱特点及创伤后应激障碍(PTSD)症状进行了调查。确定了年轻时血脂异常的形成以及相关动脉粥样硬化变化对神经内分泌效应的依赖性,这些效应伴随着战斗压力的影响并促进加速衰老。另一方面,随着时间的推移,在参战15至25年后,PTSD的强度及其对脂质谱异常发展的影响可能会下降。血脂异常发病机制中的主导作用在于与战斗行动退伍军人加速衰老过程相关的年龄相关变化,以及与酒精滥用和传染病后果相关的肝脏代谢病理紊乱。