NMDA antagonists as Parkinson's disease therapy: disseminating the evidence.

Oral levodopa is the current baseline therapy in the management of Parkinson's disease, but nonmotor complications and therapy-related dyskinesias pose an important challenge for clinicians. Glutamate receptors have been implicated in the neurodegenerative process of Parkinson's disease and also in the development of levodopa-induced dyskinesias. This article discusses the role of NMDA receptors in Parkinson's disease and their modulation as a possible therapeutic approach.