肽合成和生物共轭中的苯硫代氨基甲酸酯或N-碳硫苯基化学。
Phenylthiocarbamate or N-carbothiophenyl group chemistry in peptide synthesis and bioconjugation.
作者信息
Melnyk Oleg, Ollivier Nathalie, Besret Soizic, Melnyk Patricia
机构信息
UMR CNRS 8161 , F-59021 Lille, France.
出版信息
Bioconjug Chem. 2014 Apr 16;25(4):629-39. doi: 10.1021/bc500052r. Epub 2014 Mar 28.
Abstract
The design of novel chemoselective and site-specific ligation methods provides new tools for obtaining complex scaffolds, peptidomimetics, and peptide conjugates. The chemistry of the N-phenylthiocarbonyl group has led to several developments in peptide ligation chemistry and peptide bioconjugation during the last 10 years. The aim of this review is to provide an overview of this emerging field.
摘要
新型化学选择性和位点特异性连接方法的设计为获得复杂支架、拟肽和肽缀合物提供了新工具。在过去十年中，N-苯基硫代羰基基团的化学性质推动了肽连接化学和肽生物共轭领域的多项进展。本综述的目的是对这一新兴领域进行概述。
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