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产后出血管理、风险和产妇结局:来自世界卫生组织母婴健康多国调查的结果。

Postpartum haemorrhage management, risks, and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health.

机构信息

Gynuity Health Projects, New York, NY, USA.

出版信息

BJOG. 2014 Mar;121 Suppl 1:5-13. doi: 10.1111/1471-0528.12636.

Abstract

OBJECTIVE

To explore the clinical practices, risks, and maternal outcomes associated with postpartum haemorrhage (PPH).

DESIGN

Secondary analysis of cross-sectional data.

SETTING

A total of 352 health facilities in 28 countries.

SAMPLE

A total of 274 985 women giving birth between 1 May 2010 and 31 December 2011.

METHODS

We used multivariate logistic regression to examine factors associated with PPH among all births, and the Pearson chi-square test to examine correlates of severe maternal outcomes (SMOs) among women with PPH. All analyses adjust for facility- and country-level clustering.

MAIN OUTCOME MEASURES

PPH, SMOs, and clinical practices for the management of PPH.

RESULTS

Of all the women included in the analysis, 95.3% received uterotonic prophylaxis and the reported rate of PPH was 1.2%. Factors significantly associated with PPH diagnosis included age, parity, gestational age, induction of labour, caesarean section, and geographic region. Among those with PPH, 92.7% received uterotonics for treatment, and 17.2% had an SMO. There were significant differences in the incidence of SMOs by age, parity, gestational age, anaemia, education, receipt of uterotonics for prophylaxis or treatment, referral from another facility, and Human Development Index (HDI) group. The rates of death were highest in countries with low or medium HDIs.

CONCLUSIONS

Among women with PPH, disparities in the incidence of severe maternal outcomes persist, even among facilities that report capacity to provide all essential emergency obstetric interventions. This highlights the need for better information about the role of institutional capacity, including quality of care, in PPH-related morbidity and mortality.

摘要

目的

探讨产后出血(PPH)相关的临床实践、风险和产妇结局。

设计

横断面数据的二次分析。

设置

28 个国家的 352 家卫生机构。

样本

2010 年 5 月 1 日至 2011 年 12 月 31 日期间分娩的 274985 名妇女。

方法

我们使用多变量逻辑回归分析了所有分娩中与 PPH 相关的因素,并使用 Pearson 卡方检验分析了 PPH 妇女中严重产妇结局(SMO)的相关因素。所有分析均调整了设施和国家层面的聚类。

主要观察指标

PPH、SMO 和 PPH 管理的临床实践。

结果

在纳入分析的所有妇女中,95.3%接受了宫缩素预防,报告的 PPH 发生率为 1.2%。与 PPH 诊断显著相关的因素包括年龄、产次、胎龄、引产、剖宫产和地理区域。在 PPH 妇女中,92.7%接受了宫缩素治疗,17.2%发生了 SMO。年龄、产次、胎龄、贫血、教育程度、预防或治疗用宫缩素的使用、来自其他医疗机构的转诊以及人类发展指数(HDI)组均与 SMO 的发生率存在显著差异。死亡率最高的是 HDI 较低或中等的国家。

结论

在患有 PPH 的妇女中,即使在报告有能力提供所有基本紧急产科干预的医疗机构中,严重产妇结局的发生率仍存在差异。这凸显了更好地了解机构能力(包括护理质量)在 PPH 相关发病率和死亡率中的作用的必要性。

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