Department of Physiology, Medical School, University of Patras, Rio, 26504 Patras, Greece.
Department of Biology, Medical School, University of Patras, Rio, 26504 Patras, Greece.
Semin Cell Dev Biol. 2014 Jun;30:174-80. doi: 10.1016/j.semcdb.2014.03.013. Epub 2014 Mar 15.
Recent findings provide evidence for a functional interplay between DNA replication and the seemingly distinct areas of cancer, development and pluripotency. Protein complexes participating in DNA replication origin licensing are now known to have roles in development, while their deregulation can lead to cancer. Moreover, transcription factors implicated in the maintenance of or reversal to the pluripotent state have links to the pre-replicative machinery. Several studies have shown that overexpression of these factors is associated to cancer.
最近的研究结果为 DNA 复制与癌症、发育和多能性这看似截然不同的领域之间的功能相互作用提供了证据。参与 DNA 复制起始许可的蛋白质复合物现在已知在发育过程中发挥作用，而它们的失调可能导致癌症。此外，涉及维持或逆转多能状态的转录因子与前复制机制有关。几项研究表明，这些因子的过表达与癌症有关。
