[肌纤维膜钾通道与短杆菌肽通道的阳离子特异性]
[The cation specificity of the potassium and gramicidin channels of muscle fiber membrane].
作者信息
Shvinka N E, Caffier G
出版信息
Tsitologiia. 1988 Sep;30(9):1101-7.
Conductance ratios (Gi/Gk) and permeability ratios (Pi/Pk) for monovalent cations in frog muscle fibres have been defined under constant current conditions using a double sucrose gap method. Selectivity determined from potassium channel conductance is: K+ greater than Rb+ greater than Cs+ greater than greater than NH4+ greater than Na+ greater than Li+. In gramicidin channels both the permeability and conductance sequences are identical: NH4+ greater than Cs+ greater than Rb+ greater than K+ greater than Na+ greater than Li+. In isotonic K+-sulfate solution with one-sided addition of external [Tl+] (2.5 x 10(-3)-20 x 10(-3) M), differences in the conductance and permeability ratios for gramicidin channel were observed.
蛙肌纤维中单价阳离子的电导比（Gi/Gk）和渗透率比（Pi/Pk）已在恒定电流条件下使用双蔗糖间隙法进行了定义。由钾通道电导确定的选择性为：K⁺＞Rb⁺＞Cs⁺＞＞NH₄⁺＞Na⁺＞Li⁺。在短杆菌肽通道中，渗透率和电导序列相同：NH₄⁺＞Cs⁺＞Rb⁺＞K⁺＞Na⁺＞Li⁺。在等渗硫酸钾溶液中单侧添加外部[Tl⁺]（2.5×10⁻³ - 20×10⁻³ M）时，观察到短杆菌肽通道的电导比和渗透率比存在差异。
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