黏附 GPCR 家族中的 BAI 亚家族：突触调节及其他功能。
The BAI subfamily of adhesion GPCRs: synaptic regulation and beyond.
机构信息
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Trends Pharmacol Sci. 2014 Apr;35(4):208-15. doi: 10.1016/j.tips.2014.02.002. Epub 2014 Mar 15.
The brain-specific angiogenesis inhibitors 1-3 (BAI1-3) comprise a subfamily of adhesion G-protein-coupled receptors (GPCRs). These receptors are highly expressed in the brain and were first studied for their ability to inhibit angiogenesis and tumor formation. Subsequently, BAI1 was found to play roles in apoptotic cell phagocytosis and myoblast fusion. Until recently, however, little was known about the physiological importance of the BAI subfamily in the context of normal brain function. Recent work has provided evidence for key roles of BAI1-3 in the regulation of synaptogenesis and dendritic spine formation. In this review, we summarize the current understanding of the BAI subfamily with regard to downstream signaling pathways, physiological actions, and potential importance as novel drug targets in the treatment of psychiatric and neurological diseases.
脑特异性血管生成抑制剂 1-3（BAI1-3）是粘附 G 蛋白偶联受体（GPCR）的一个亚家族。这些受体在大脑中高度表达，最初因其抑制血管生成和肿瘤形成的能力而被研究。随后，发现 BAI1 在凋亡细胞吞噬和成肌细胞融合中发挥作用。然而，直到最近，人们对 BAI 亚家族在正常大脑功能中的生理重要性知之甚少。最近的工作为 BAI1-3 在调节突触发生和树突棘形成中的关键作用提供了证据。在这篇综述中，我们总结了目前对 BAI 亚家族的理解，包括下游信号通路、生理作用以及作为治疗精神和神经疾病的新型药物靶点的潜在重要性。
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