Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Phahonyothin Rd Klonglung, PathumThani, 12120, Thailand.
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Phahonyothin Rd Klonglung, PathumThani, 12120, Thailand.
Crit Rev Oncol Hematol. 2017 Mar;111:81-86. doi: 10.1016/j.critrevonc.2017.01.006. Epub 2017 Jan 16.
Brain-specific angiogenesis inhibitor (BAI) family of proteins are basically putative G-protein-coupled receptors with wide spectrum of cellular activities. These BAIs exhibit intricate and complex nature of modulatory activities that researchers are only now beginning to understand. Here we mainly focus on the regulatory activities of a prominent member of BAI family, BAI1, with respect to its role in inflammation, tumorigenesis and phagocytosis. The emerging knowledge on cell- and site-specific function of BAI1 makes it both versatile and promising candidate for studies relating to cancer and host immune response. This review collectively specifies and comprehends important findings of BAI1 from several studies and provides latest insight to explore its properties for possible biomedical therapeutics.
脑特异性血管生成抑制剂（BAI）家族蛋白基本上是假定的 G 蛋白偶联受体，具有广泛的细胞活性。这些 BAI 表现出复杂和多样化的调节活性，研究人员现在才开始理解。在这里，我们主要关注 BAI 家族中一个突出成员 BAI1 的调节活性，以及它在炎症、肿瘤发生和吞噬作用中的作用。关于 BAI1 的细胞和位点特异性功能的新知识，使它成为与癌症和宿主免疫反应相关研究的多功能和有前途的候选者。这篇综述综合了从几项研究中获得的关于 BAI1 的重要发现，并提供了最新的见解，以探索其特性，用于可能的生物医学治疗。
