Department of Urology, Gaochun County Hospital, Nanjing, China.
PLoS One. 2014 Mar 18;9(3):e92079. doi: 10.1371/journal.pone.0092079. eCollection 2014.
Recently, many studies explored the role of inflammation parameters such as neutrophil-to-lymphocyte ratio (NLR) in the prognosis of urinary cancers, but the results were not consistent.
We carried out a meta-analysis of published studies to assess the prognostic value of NLR in patients with urinary cancers. Hazard ratio (OR) with 95% confidence interval (CI) was used to assess the association of NLR and OS and RFS/CSS.
The pooled results showed that high NLR was a poor predictor for OS with HR of 1.81 (95%CI: 1.48-2.21; Pheterogeneity = 0.005) and RFS/CSS (HR = 2.07, 95% CI: 1.65-2.6; Pheterogeneity = 0.849). Subgroup analyses revealed that high NLR yielded a worse OS in RCC (HR = 1.9, 95%CI: 1.47-2.45; Pheterogeneity = 0.003) and a poor RFS/CSS in RCC (HR = 1.83, 95%CI: 1.35-2.48; Pheterogeneity = 0.709), bladder cancer (HR = 2.2, 95%CI: 1.27-3.8; Pheterogeneity = 0.447) and urothelial carcinoma (HR = 2.58, 95%CI: 1.66-4.01; Pheterogeneity = 0.784).
Our results showed that NLR could act as a significant biomarker in the prognosis of urinary cancers.
最近，许多研究探讨了炎症参数如中性粒细胞与淋巴细胞比值（NLR）在尿路上皮癌预后中的作用，但结果并不一致。
我们对已发表的研究进行了荟萃分析，以评估 NLR 在尿路上皮癌患者中的预后价值。风险比（HR）和 95%置信区间（CI）用于评估 NLR 与 OS 和 RFS/CSS 的相关性。
汇总结果表明，高 NLR 是 OS 的不良预测因子，HR 为 1.81（95%CI：1.48-2.21；P异质性=0.005）和 RFS/CSS（HR=2.07，95%CI：1.65-2.6；P异质性=0.849）。亚组分析表明，高 NLR 在 RCC 中导致更差的 OS（HR=1.9，95%CI：1.47-2.45；P异质性=0.003），在 RCC 中导致更差的 RFS/CSS（HR=1.83，95%CI：1.35-2.48；P异质性=0.709），在膀胱癌（HR=2.2，95%CI：1.27-3.8；P异质性=0.447）和尿路上皮癌（HR=2.58，95%CI：1.66-4.01；P异质性=0.784）中。
我们的结果表明，NLR 可以作为尿路上皮癌预后的一个有意义的生物标志物。
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