Ivanić Davor, Đug Haris, Jagodić Samed, Delibegović Samir
Clinic for Urology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.
Clinic for Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.
Int Urol Nephrol. 2025 Apr;57(4):1143-1149. doi: 10.1007/s11255-024-04297-x. Epub 2024 Nov 27.
To predict oncological outcomes and select appropriate treatments for non-muscle-invasive bladder cancer (NMIBC), pre-treatment predictors such as neutrophil-to-lymphocyte ratio (NLR) are being used. This study aims to evaluate whether NLR is an independent predictor of disease and disease recurrence in NMIBC patients.
In this prospective clinical study, from March 2018 to March 2023, preoperative NLR values were monitored in 99 patients newly diagnosed with NMIBC, who were initially treated with trans-urethral resection of bladder tumor (TURBT) and adjuvant intravesical therapy. To evaluate the best NLR cutoff points to predict recurrence, the ROC (receiver operating characteristic) curve and the Youden index were used. The monitoring period was 24 months.
With the cutoff value of NLR = 1.73, there is a statistically significant correlation (p = 0.008) between the NLR value and the increased risk of recurrence. Univariate and multivariate Cox regression analyses show the significant prognostic impact of NLR on the recurrence of the disease.
The value of NLR > 1.73 is a significant preoperative predictor in risk assessment and will help with proper selection of treatment in the high- and intermediate-risk groups of patients.
为预测非肌层浸润性膀胱癌(NMIBC)的肿瘤学结局并选择合适的治疗方法,正在使用中性粒细胞与淋巴细胞比值(NLR)等治疗前预测指标。本研究旨在评估NLR是否是非肌层浸润性膀胱癌患者疾病及疾病复发的独立预测指标。
在这项前瞻性临床研究中,2018年3月至2023年3月期间,对99例新诊断为非肌层浸润性膀胱癌的患者术前NLR值进行监测,这些患者最初接受经尿道膀胱肿瘤切除术(TURBT)及辅助膀胱内治疗。为评估预测复发的最佳NLR临界值,采用了ROC(受试者工作特征)曲线和尤登指数。监测期为24个月。
NLR临界值为1.73时,NLR值与复发风险增加之间存在统计学显著相关性(p = 0.008)。单因素和多因素Cox回归分析显示NLR对疾病复发具有显著的预后影响。
NLR>1.73的值是风险评估中一个重要的术前预测指标,将有助于在中高危患者组中合理选择治疗方法。