Durmus Ahmet, Mentese Ahmet, Yilmaz Mustafa, Sumer Aysegul, Akalin Ibrahim, Topal Cevat, Alver Ahmet
Department of Hematology, Internal Medicine, Kanuni Training and Research Hospital, Trabzon, Turkey.
Med Princ Pract. 2014;23(3):253-8. doi: 10.1159/000360102. Epub 2014 Mar 15.
This study was designed to compare the oxidative stress parameters of patients with polycythemia vera (PV) to those of healthy volunteers and to investigate the probable relationship between vascular events and parameters of oxidative status such as total oxidative status (TOS), total antioxidant status, oxidative stress index (OSI) and malondialdehyde (MDA) in PV patients.
Thirty-five PV patients (20 males and 15 females) and 20 healthy volunteers (11 males and 9 females) were enrolled. The oxidative status parameters of the patients were measured by spectrophotometric analyses at the time of diagnosis and at 6 months after treatment which consisted of phlebotomy and 100 mg/day acetyl salicylic acid with or without hydroxyurea for the high- and low-risk disease group, respectively. These parameters were compared both to healthy controls and to each other, in order to obtain the values before and after treatment. In addition, during diagnosis, the oxidative status parameters of patients with PV and a history of a vascular event were compared with those of patients with no history of a vascular event.
The TOS, OSI and MDA values were significantly higher in the patients than in the control group at the time of diagnosis. At 6 months after phlebotomy and 100 mg/day acetyl salicylic acid therapy, the TOS, OSI and MDA values were significantly lower in the patients when compared to the pretreatment values. The TOS and OSI levels were notably higher in the patients with a vascular-event history than in those without this history.
Oxidative stress parameters were increased in PV patients.
本研究旨在比较真性红细胞增多症（PV）患者与健康志愿者的氧化应激参数，并调查PV患者血管事件与氧化状态参数（如总氧化状态（TOS）、总抗氧化状态、氧化应激指数（OSI）和丙二醛（MDA））之间的可能关系。
招募了35例PV患者（20例男性和15例女性）和20名健康志愿者（11例男性和9例女性）。在诊断时以及治疗6个月后，通过分光光度分析测量患者的氧化状态参数，治疗方案分别为对高危和低危疾病组进行放血以及每天服用100mg乙酰水杨酸，高危组加用或不加用羟基脲。将这些参数与健康对照组进行比较，并相互比较，以获得治疗前后的值。此外，在诊断期间，将有血管事件病史的PV患者的氧化状态参数与无血管事件病史的患者进行比较。
诊断时患者的TOS、OSI和MDA值显著高于对照组。在放血和每天服用100mg乙酰水杨酸治疗6个月后，患者的TOS、OSI和MDA值与治疗前相比显著降低。有血管事件病史的患者的TOS和OSI水平明显高于无此病史的患者。
PV患者的氧化应激参数升高。
