Cosmetic Research Center, Coway Co. Ltd., 459-11 Gasan-dong, Geumcheon-gu, Seoul, South Korea.
Arch Pharm Res. 2014 Apr;37(4):423-34. doi: 10.1007/s12272-014-0342-4. Epub 2014 Feb 11.
Recently a variety of polymeric vehicles, such as micelles, nanoparticles, and polymersomes, have been explored and some of them are clinically used to deliver therapeutic drugs through skin. In topical delivery, the polymeric vehicles as drug carrier should guarantee non-toxicity, long-term stability, and permeation efficacy for drugs, etc. For the development of the successful topical delivery system, it is of importance to develop the polymeric vehicles of well-defined intrinsic properties, such as molecular weights, HLB, chemical composition, topology, specific ligand conjugation and to investigate the effects of the properties on drug permeation behavior. In addition, the role of polymeric vehicles must be elucidated in in vitro and in vivo analyses. This article describes some important features of polymeric vehicles and corresponding analytical methods in topical delivery even though the application span of polymers has been truly broad in the pharmaceutical fields.
最近，人们探索了多种聚合物载体，如胶束、纳米粒和聚合物囊泡等，并将其中一些用于经皮递药。在局部递药中，聚合物载体作为药物载体应保证药物的无毒、长期稳定性和渗透效果等。为了开发成功的局部递药系统，开发具有明确内在特性的聚合物载体非常重要，如分子量、HLB、化学组成、拓扑结构、特定配体缀合等，并研究这些特性对药物渗透行为的影响。此外，聚合物载体的作用必须在体外和体内分析中阐明。本文描述了局部递药中聚合物载体的一些重要特性和相应的分析方法，尽管聚合物的应用范围在制药领域确实很广泛。
