Bravi Luca, Dejana Elisabetta, Lampugnani Maria Grazia
FIRC Institute of Molecular Oncology (IFOM) Fondazione, Via Adamello 16, 20139, Milan, Italy.
Cell Tissue Res. 2014 Mar;355(3):515-22. doi: 10.1007/s00441-014-1843-7. Epub 2014 Mar 20.
Although being a monolayer the vascular endothelium controls fundamental vessel functions such as permeability, leukocyte extravasation and angiogenesis. The endothelial selective transmembrane constituent of adherens junctions, Vascular Endothelial- (VE-) cadherin plays a crucial role in the regulation of such activities. The signaling pathways controlled by VE-cadherin as well as the ones that regulate VE-cadherin activity start to be elucidated. This delineates a complex network of molecular and functional interactions that can be altered in pathologies.
尽管血管内皮是单层结构，但它控制着诸如通透性、白细胞外渗和血管生成等基本血管功能。黏附连接的内皮选择性跨膜成分血管内皮（VE）-钙黏蛋白在调节这些活动中起关键作用。由VE-钙黏蛋白控制的信号通路以及调节VE-钙黏蛋白活性的信号通路开始得到阐明。这描绘了一个复杂的分子和功能相互作用网络，该网络在病理状态下可能会发生改变。
