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[通过伏安法在睡眠-觉醒周期中测量背侧中缝核轴突终末和细胞体的5-羟吲哚乙酸（5-HIAA）细胞外浓度的相反变化]

[Opposite variations of extracellular concentrations of 5-hydroxyindoleacetic acid (5-HIAA) measured by voltammetry of axonal terminals and cell bodies of the dorsal raphe nucleus through the sleep-wake cycle].

作者信息

Cespuglio R, Chastrette N, Jouvet M

机构信息

Laboratoire de Médecine expérimentale, I.N.S.E.R.M., Lyon.

出版信息

C R Acad Sci III. 1988;307(18):817-23.

PMID:2464425
Abstract

Differential pulse voltammetry was used for 5-hydroxyindoleacetic acid (5-HIAA) detection in the rat caudate (n. Cd) and Raphe Dorsalis (n. RD) nuclei, in chronic experimental conditions. In the anterior and ventral part of n. RD, large increases in the extracellular concentrations of 5-HIAA were reported during slow wave sleep (SWS) and paradoxical sleep (PS) whereas a decrease occurred during waking. These variations could reflect the dendritic release of serotonin. In n. Cd, opposite variations of the extracellular concentrations of 5-HIAA were observed i.e. increase during waking state and decrease during SWS and PS.

摘要

在慢性实验条件下，采用差分脉冲伏安法检测大鼠尾状核（Cd核）和中缝背核（RD核）中的5-羟吲哚乙酸（5-HIAA）。在RD核的前部和腹侧部分，据报道在慢波睡眠（SWS）和异相睡眠（PS）期间细胞外5-HIAA浓度大幅增加，而在清醒期间则降低。这些变化可能反映了5-羟色胺的树突状释放。在Cd核中，观察到细胞外5-HIAA浓度的相反变化，即在清醒状态下增加，而在SWS和PS期间降低。

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引用本文的文献

1
Voltammetric detection of the release of 5-hydroxyindole compounds throughout the sleep-waking cycle of the rat.伏安法检测大鼠睡眠-清醒周期中5-羟吲哚化合物的释放情况。
Exp Brain Res. 1990;80(1):121-8. doi: 10.1007/BF00228853.