Zhao Yan, Li Yan-Yan
Yi Chuan. 2013 Dec;35(12):1360-7. doi: 10.3724/sp.j.1005.2013.01360.
Safety assessment is the essential process for commercial application of genetically modified (GM) crops. Omics techniques can be used to evaluate the safety of GM crops unbiasedly at different biological levels, such as transcripts, proteins and metabolites. In the present review, the researches on unintended effects assessment of GM crops using transcriptomic, proteomic and metabolomic techniques in recent ten years have been summarized. The facts show that the environmental factors (growing area and season) and genotype difference play greater roles than gene insertion does for most unintended variations in GM crops.
安全性评估是转基因作物商业化应用的关键过程。组学技术可用于在不同生物水平上无偏倚地评估转基因作物的安全性，如转录本、蛋白质和代谢物水平。在本综述中，总结了近十年来利用转录组学、蛋白质组学和代谢组学技术对转基因作物非预期效应评估的研究。事实表明，对于转基因作物的大多数非预期变异，环境因素（种植区域和季节）和基因型差异比基因插入所起的作用更大。
