Radjei Sabrina, Friguet Bertrand, Nizard Carine, Petropoulos Isabelle
∥LVMH Recherche, 185 avenue de Verdun, 45800 Saint-Jean-de-Braye, France.
Biochem Soc Trans. 2014 Apr;42(2):518-22. doi: 10.1042/BST20140017.
Skin aging is the result of intrinsic chronological aging and photoaging, due to UV exposure, that both share important histological modifications and molecular features, including alterations of proteins. One of the main damage is glycation that occurs when reducing sugars react non-enzymatically with proteins. This reaction also happens when the dicarbonyl compounds GO (glyoxal) and MG (methylglyoxal), which are glucose derivatives, react with proteins. These compounds can be detoxified by the glyoxalase system composed of two enzymes, Glo1 (glyoxalase I) and Glo2 (glyoxalase II). The aims of the present mini-review are to briefly summarize our current knowledge of the biological roles of these enzymes in aging and then discuss the relevance of studying the role of glycation and of detoxifying systems in human skin aging.
皮肤老化是内源性自然老化和光老化的结果，光老化是由于紫外线照射所致，这两种老化都具有重要的组织学改变和分子特征，包括蛋白质的改变。主要损伤之一是糖基化，即还原糖与蛋白质发生非酶促反应时发生的现象。当葡萄糖衍生物二羰基化合物乙二醛（GO）和甲基乙二醛（MG）与蛋白质反应时，也会发生这种反应。这些化合物可被由两种酶，即乙二醛酶I（Glo1）和乙二醛酶II（Glo2）组成的乙二醛酶系统解毒。本小型综述的目的是简要总结我们目前对这些酶在衰老中的生物学作用的认识，然后讨论研究糖基化和解毒系统在人类皮肤老化中的作用的相关性。
