Wortmann Markus, Peters Andreas S, Hakimi Maani, Böckler Dittmar, Dihlmann Susanne
*Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany.
Biochem Soc Trans. 2014 Apr;42(2):528-33. doi: 10.1042/BST20140003.
Glo1 (glyxoalase I) is a cytosolic protein expressed in all mammalian cells. Its physiological function is the detoxification of MG (methylglyoxal), which is a potent precursor of AGEs (advanced glycation end-products). Although the impact of AGEs on different forms of vascular diseases has been intensively investigated, the evidence for the involvement of Glo1 and MG is still scarce. Recently, several studies have provided significant evidence for Glo1 having a protective effect on microvascular complications in diabetic patients, such as retinopathy and nephropathy. Regarding macrovascular complications, especially atherosclerotic lesions, the impact of Glo1 is even less clear. In the present article, we review the latest findings regarding the role of Glo1 and MG in vascular biology and the pathophysiology of micro- and macro-vascular disease.
乙二醛酶I（Glo1）是一种在所有哺乳动物细胞中表达的胞质蛋白。其生理功能是对甲基乙二醛（MG）进行解毒，甲基乙二醛是晚期糖基化终产物（AGEs）的一种强效前体。尽管AGEs对不同形式血管疾病的影响已得到深入研究，但关于Glo1和MG参与其中的证据仍然很少。最近，几项研究提供了重要证据，表明Glo1对糖尿病患者的微血管并发症（如视网膜病变和肾病）具有保护作用。关于大血管并发症，尤其是动脉粥样硬化病变，Glo1的影响甚至更不明确。在本文中，我们综述了关于Glo1和MG在血管生物学以及微血管和大血管疾病病理生理学中作用的最新发现。
