Guibaud S, Boisson C, Simplot A, Thoulon J M
Laboratoire de Biochimie, Hôpital de la Croix-Rousse, Lyon.
J Genet Hum. 1988 Aug;36(4):337-46.
Increasing number of amniocentesis done during the second half of gestation with indication "signe d'appel" made necessary for authors to study amniotic fluid markers in late pregnancy. Normal evolution curve must be established with samples obtained after 20 weeks gestation. Study reveals more false-negative results with AFP than before 20 weeks. AChE remains constantly positive in cases with NTD, band aspect being specific. For other malformations, AChE positivity seems inconstant, with a different aspect. Some normal gestation cases can be associated with faint AChE band.
妊娠后半期羊膜穿刺术的数量不断增加，其指征为“紧急信号”，这使得作者有必要研究晚期妊娠的羊水标志物。必须用妊娠20周后获得的样本建立正常的演变曲线。研究显示，与妊娠20周前相比，甲胎蛋白（AFP）的假阴性结果更多。在神经管缺陷（NTD）病例中，乙酰胆碱酯酶（AChE）始终呈阳性，条带特征具有特异性。对于其他畸形，AChE阳性似乎并不恒定，表现有所不同。一些正常妊娠病例可能伴有微弱的AChE条带。
