Yamashita Y, Koike K, Takaoki M, Matsuda S
Central Research Division, Takeda Chemical Industries, Ltd., Osaka.
Microbiol Immunol. 1988;32(11):1119-26. doi: 10.1111/j.1348-0421.1988.tb01476.x.
Recombinant human interferon alpha 2a as well as natural human interferons alpha and beta significantly suppressed the production of hepatitis B surface antigen by PLC/PRF/5 cells (which have been established from a human primary hepatocellular carcinoma and proven to carry the hepatitis B virus DNA) and inhibited proliferation of these cells in vitro. However, the production of alpha-fetoprotein by PLC/PRF/5 cells was less significantly affected by any of the interferons. These results suggest that these interferons not only suppress cellular proliferation but also selectively inhibit the action of the HBV gene which is persistently present in these cells.
重组人干扰素α2a以及天然人干扰素α和β显著抑制了PLC/PRF/5细胞（该细胞系从人原发性肝细胞癌建立，并被证明携带乙肝病毒DNA）中乙肝表面抗原的产生，并在体外抑制了这些细胞的增殖。然而，PLC/PRF/5细胞中甲胎蛋白的产生受任何一种干扰素的影响都较小。这些结果表明，这些干扰素不仅抑制细胞增殖，还选择性地抑制这些细胞中持续存在的乙肝病毒基因的作用。
