干扰素-ω抑制人肝癌细胞系中乙型肝炎表面抗原的产生。
Interferon-omega suppresses hepatitis B surface antigen production in human hepatoma cell line.
作者信息
Hajnická V, Fuchsberger N, Liptáková H, Stancek D, Kontsek P
机构信息
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
出版信息
Acta Virol. 1996 Sep;40(4):221-2.
Biological activities of human interferon (IFN) omega are less well characterized than those of other type I human IFNs. We compared the ability of recombinant IFN-omega, IFN-alpha 2 and IFN-gamma to inhibit the production of viral hepatitis B surface antigen (HBsAg) in the human hepatoma cell line PLC/PRF/5. The results demonstrated that the capacity of IFN-omega to suppress the HBsAg synthesis was similar to that of IFN-alpha 2. The kinetics of the inhibitory effect of IFN-gamma differed from those of the two other IFNs.
人ω干扰素（IFN）的生物学活性不如其他I型人干扰素那样得到充分表征。我们比较了重组IFN-ω、IFN-α2和IFN-γ抑制人肝癌细胞系PLC/PRF/5中乙型肝炎病毒表面抗原（HBsAg）产生的能力。结果表明，IFN-ω抑制HBsAg合成的能力与IFN-α2相似。IFN-γ的抑制作用动力学与其他两种干扰素不同。
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