Zhang Peng, Wu Cuiying, Liu Ning, Niu Lijun, Yan Zhongjie, Feng Yanyan, Xu Ruxiang
Bayi Brain Hospital, Bayi Clinical Medical Institute, Southern Medical University, Beijing, China.
J Mol Neurosci. 2014;54(2):199-210. doi: 10.1007/s12031-014-0275-x. Epub 2014 Mar 20.
Protocadherin 11 X-linked (Pcdh11x) protein is a member of the cadherin superfamily with established roles in cell adhesion. Previous studies have shown the molecular biology and possible relevance of Pcdh11x with neurological disease in humans. However, little is known about the neurophysiological function of Pcdh11x in neural development. Here, we verified that Pcdh11x is primarily expressed in various brain areas including the cortex, hippocampus, and ventricular/subventricular zone (VZ/SVZ) at different embryonic stages. Furthermore, both in vitro and in vivo experiments showed that Pcdh11x decreased neural differentiation but increased the neural proliferation. These observations demonstrate a crucial function for Pcdh11x during the development of central nervous system.
X连锁原钙黏蛋白11（Pcdh11x）是钙黏蛋白超家族的成员，在细胞黏附中发挥着既定作用。先前的研究已经揭示了Pcdh11x的分子生物学特性以及它与人类神经疾病的潜在关联。然而，关于Pcdh11x在神经发育中的神经生理功能却知之甚少。在此，我们证实Pcdh11x在不同胚胎阶段主要表达于包括皮层、海马体以及脑室/室下区（VZ/SVZ）在内的各个脑区。此外，体外和体内实验均表明，Pcdh11x会减少神经分化，但会增加神经增殖。这些观察结果证明了Pcdh11x在中枢神经系统发育过程中具有关键作用。
