Department of General Surgery, Meram Medical Faculty, Selcuk University, Konya, Turkey.
Breast Care (Basel). 2012 Oct;7(5):394-6. doi: 10.1159/000343299.
Axillary lymph node dissection plays an important role in breast cancer management in terms of staging, prediction of prognosis, determination of adjuvant therapy, and local control of the primary tumor. The objective of this study was to evaluate the axillary lymph node involvement in multicentric breast tumors and breast tumors with nipple involvement in comparison with unifocal tumors.
We reviewed the records of 267 patients with stage I or IIA disease. The rates of axillary lymph node metastasis (ALNM) in patients with unifocal tumors, multicentric tumors, or nipple involvement were compared.
209 (78%) patients had unifocal tumors, 24 (8%) had multicentric tumors, and 34 (12%) had nipple involvement. The incidence of ALNM was 9.76% in patients with unifocal tumors, 24.84% in patients with multicentric tumors, and 36.71% in patients with nipple involvement. Hence, the incidence of ALNM was significantly higher in patients with nipple involvement or multicentric tumors than in patients with unifocal tumors.
Our data suggest that compared to unifocal tumors, breast tumors with nipple involvement or multiple foci show a significantly higher incidence of ALNM which is a predictor of a poor prognosis.
腋窝淋巴结清扫术在乳腺癌的分期、预后预测、辅助治疗的确定以及原发肿瘤的局部控制方面发挥着重要作用。本研究旨在评估多中心乳腺癌和伴有乳头受累的乳腺癌与单发肿瘤相比腋窝淋巴结受累情况。
我们回顾了 267 例 I 期或 IIA 期患者的记录。比较了单发肿瘤、多中心肿瘤或乳头受累患者的腋窝淋巴结转移（ALNM）率。
209 例（78%）患者为单发肿瘤，24 例（8%）为多中心肿瘤，34 例（12%）为乳头受累。单发肿瘤患者的 ALNM 发生率为 9.76%，多中心肿瘤患者为 24.84%，乳头受累患者为 36.71%。因此，乳头受累或多中心肿瘤患者的 ALNM 发生率明显高于单发肿瘤患者。
我们的数据表明，与单发肿瘤相比，伴有乳头受累或多个病灶的乳腺癌腋窝淋巴结受累的发生率明显更高，这是预后不良的预测因素。
