Women's College Research Institute, Women's College Hospital, and The University of Toronto, Toronto, Ontario, Canada.
Breast Cancer (Dove Med Press). 2014 Feb 17;6:29-36. doi: 10.2147/BCTT.S43763. eCollection 2014.
Tamoxifen has been used as a treatment for women who have been diagnosed with breast cancer for roughly four decades and has been approved as chemoprevention for over ten years. Although tamoxifen has been proven to be beneficial in preventing breast cancer in high-risk women, its use has not been widely embraced. To some extent, this is due to several of its side effects, including an increased risk of endometrial cancer and pulmonary embolism, but these serious side effects are rare. The risks and benefits of tamoxifen chemoprevention should be considered for each patient.
他莫昔芬已被用作治疗女性乳腺癌的药物，大约有四十年的历史，并且已经被批准用于乳腺癌化学预防超过十年。虽然他莫昔芬已被证明对预防高危女性的乳腺癌有益，但它的使用并未得到广泛接受。在某种程度上，这是由于其一些副作用，包括子宫内膜癌和肺栓塞风险增加，但这些严重的副作用很少见。应考虑每位患者使用他莫昔芬化学预防的风险和益处。
