放射治疗和免疫治疗在淋巴瘤治疗中的作用。
The Roles of Radiotherapy and Immunotherapy for the Treatment of Lymphoma.
作者信息
Kimball Amy S, Webb Tonya J
机构信息
Departments of Medicine and Microbiology and Immunology, and Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.
出版信息
Mol Cell Pharmacol. 2013 Jan 1;5(1):27-38.
Abstract
Lymphoma is rising in incidence and there is a continued need for new and novel therapeutic options. Lymphomas are extremely radiosensitive, but the majority of patients are not candidates for involved field radiation therapy. An intact immune system has a critical role in suppressing lymphomagenesis. Here we discuss the contribution of various components of the immune system in suppressing the development of lymphoma, as elucidated from mouse models. We review the nature of the immune response to lymphoma in non-immunocompromised patients. Finally, we discuss the potential role of immunomodulation, in concert with radiation therapy, as a component of future therapeutic strategies for lymphoma.
摘要
淋巴瘤的发病率正在上升，因此持续需要新的和新颖的治疗选择。淋巴瘤对放疗极为敏感，但大多数患者并不适合进行受累野放射治疗。完整的免疫系统在抑制淋巴瘤发生中起着关键作用。在此，我们讨论从小鼠模型中所阐明的免疫系统各组分在抑制淋巴瘤发展中的作用。我们回顾了非免疫受损患者对淋巴瘤免疫反应的性质。最后，我们讨论免疫调节与放射治疗协同作用作为淋巴瘤未来治疗策略组成部分的潜在作用。
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本文引用的文献
1
Limited-stage diffuse large B-cell lymphoma treated with abbreviated systemic therapy and consolidation radiotherapy: involved-field versus involved-node radiotherapy.
Cancer. 2012 Sep 1;118(17):4156-65. doi: 10.1002/cncr.26687. Epub 2012 Jan 17.
2
MALT lymphomas: pathogenesis can drive treatment.
Oncology (Williston Park). 2011 Nov 15;25(12):1134-42, 1147.
3
Chemotherapy alone for early-stage Hodgkin's lymphoma.
N Engl J Med. 2012 Feb 2;366(5):470-1. doi: 10.1056/NEJMe1113291. Epub 2011 Dec 11.
4
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times.
Br J Haematol. 2012 Jan;156(2):225-33. doi: 10.1111/j.1365-2141.2011.08942.x. Epub 2011 Nov 30.
5
Regulatory T cells increase in breast cancer and in stage IV breast cancer.
Cancer Immunol Immunother. 2012 Jun;61(6):911-6. doi: 10.1007/s00262-011-1158-4. Epub 2011 Nov 25.
6
In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study.
Blood. 2012 Jan 12;119(2):355-63. doi: 10.1182/blood-2011-05-355222. Epub 2011 Nov 1.
7
Cutaneous T-cell lymphoma: 2011 update on diagnosis, risk-stratification, and management.
Am J Hematol. 2011 Nov;86(11):928-48. doi: 10.1002/ajh.22139.
8
The germinal center/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed/refractory diffuse large B-cell lymphoma: a bio-CORAL study.
J Clin Oncol. 2011 Nov 1;29(31):4079-87. doi: 10.1200/JCO.2011.35.4423. Epub 2011 Sep 26.
9
The company malaria keeps: how co-infection with Epstein-Barr virus leads to endemic Burkitt lymphoma.
Curr Opin Infect Dis. 2011 Oct;24(5):435-41. doi: 10.1097/QCO.0b013e328349ac4f.
10
Pathobiology of Epstein-Barr virus-driven peripheral T-cell lymphomas.
Semin Diagn Pathol. 2011 Aug;28(3):234-44. doi: 10.1053/j.semdp.2011.02.007.
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