Ma Jing, DU Lian Fang, Chen Ming, Wang Hang Hui, Xing Ling Xi, Jing Li Fang, Li Yun Hua
Department of Ultrasound, Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200080; ; Department of Cardiovascular Ultrasound, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, P.R. China.
Department of Ultrasound, Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200080;
Biomed Rep. 2013 Jul;1(4):506-510. doi: 10.3892/br.2013.110. Epub 2013 May 21.
The nano-microcapsules drug delivery system is currently a promising method for the treatment of many types of diseases, particularly tumors. However, the drug delivery efficiency does not reach a satisfactory level to meet treatment demands. Therefore, the effectiveness of delivery needs to be improved. Based on the alterations in the structure and modification of nano-microcapsules, ultrasound-targeted microbubble destruction (UTMD), a safe physical targeted method, may increase tissue penetration and cell membrane permeability, aiding the drug-loaded nano-microcapsules ingress the interior of targeted tissues and cells. The effectiveness and exact mechanism of action of the drug-loaded nano-microcapsules delivery system mediated by UTMD have yet to be fully elucidated. In this study, the latest advancement in UTMD-mediated drug loaded nano-microcapsules system technology was reviewed and the hindrances of UTMD-mediated drug delivery were assessed, in combination with a prospective study. The findings suggested that the drug delivery efficiency of nano-microcapsules mediated by UTMD was distinctly improved. Thus, the UTMD-mediated drug-loaded nano-microcapsules delivery system may significantly improve the efficiency of drug delivery, which may be a promising new therapeutic method.
纳米微胶囊药物递送系统是目前治疗多种疾病，尤其是肿瘤的一种很有前景的方法。然而，药物递送效率尚未达到令人满意的水平以满足治疗需求。因此，需要提高递送的有效性。基于纳米微胶囊结构的改变和修饰，超声靶向微泡破坏（UTMD）作为一种安全的物理靶向方法，可增加组织穿透性和细胞膜通透性，有助于载药纳米微胶囊进入靶向组织和细胞内部。UTMD介导的载药纳米微胶囊递送系统的有效性及确切作用机制尚未完全阐明。在本研究中，结合前瞻性研究，综述了UTMD介导的载药纳米微胶囊系统技术的最新进展，并评估了UTMD介导药物递送的障碍。研究结果表明，UTMD介导的纳米微胶囊药物递送效率明显提高。因此，UTMD介导的载药纳米微胶囊递送系统可能显著提高药物递送效率，这可能是一种有前景的新治疗方法。
