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通过硬膜下电极记录确定成年顽固性局灶性癫痫患者的发作持续时间。

Seizure duration determined by subdural electrode recordings in adult patients with intractable focal epilepsy.

作者信息

Kim Daeyoung, Cho Jae-Wook, Lee Jihyun, Joo Eun Yeon, Hong Seung Chyul, Hong Seung Bong, Seo Dae-Won

机构信息

Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine;

Department of Neurology, Pusan National University Yangsan Hospital, School of Medicine;

出版信息

J Epilepsy Res. 2011 Dec 30;1(2):57-64. doi: 10.14581/jer.11011. eCollection 2011 Dec.

DOI:10.14581/jer.11011
PMID:24649447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3952333/
Abstract

BACKGROUND AND PURPOSE

To investigate the duration of seizures and its relationship to seizure type, epilepsy syndrome, and seizure clustering.

METHODS

We examined 1,251 seizures from 152 patients who underwent video-electrocorticographic monitoring with subdural electrodes. Their seizure duration, seizure types, epilepsy syndromes, and seizure clusters were analyzed.

RESULTS

The median seizure duration was 91.5s (4-1016s). There were 34 (2.7%) seizures lasting > 5 minutes in 20 (13.2%) patients. There was a significant difference in seizure duration according to seizure types (p < 0.0001), but not to epilepsy syndromes. There were 99 seizure clusters in 67 (44.1%) patients. The first seizure in a cluster of seizures tended to last longer than non-cluster seizures (median 98s versus 89s, p = 0.033). Seizure duration was significantly longer in mesial temporal lobe epilepsy than in neocortical lobe epilepsy (median 103s versus 87s, p = 0.041). Rate of seizure cluster was lower in mTLE (38.0%) than in NLE (47.1%), but this difference was not significant.

CONCLUSIONS

Seizure durations were different among seizure types. Seizure clustering also differ between patients with mTLE and those with NLE, which suggests different seizure generation and propagation among different epileptogenic foci. This study has implications for the identification of abnormally prolonged seizures.

摘要

背景与目的

研究癫痫发作的持续时间及其与发作类型、癫痫综合征和发作成簇之间的关系。

方法

我们检查了152例接受硬膜下电极视频脑电图监测患者的1251次发作。分析了他们的发作持续时间、发作类型、癫痫综合征和发作成簇情况。

结果

发作持续时间的中位数为91.5秒（4 - 1016秒）。20例（13.2%）患者中有34次（2.7%）发作持续时间超过5分钟。根据发作类型，发作持续时间存在显著差异（p < 0.0001），但与癫痫综合征无关。67例（44.1%）患者中有99次发作成簇。成簇发作中的首次发作往往比非成簇发作持续时间更长（中位数分别为98秒和89秒，p = 0.033）。内侧颞叶癫痫的发作持续时间明显长于新皮质叶癫痫（中位数分别为103秒和87秒，p = 0.041）。内侧颞叶癫痫的发作成簇率（38.0%）低于新皮质叶癫痫（47.1%），但差异不显著。

结论

不同发作类型的发作持续时间不同。内侧颞叶癫痫患者和新皮质叶癫痫患者的发作成簇情况也不同，这表明不同致痫灶之间的发作产生和传播方式不同。本研究对识别异常延长的发作具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/06c8837b763d/er-1-2-57-4f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/5fb338b4a221/er-1-2-57-4f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/b8ebff2b8f2e/er-1-2-57-4f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/a2c62d45d349/er-1-2-57-4f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/68f79a6e73f2/er-1-2-57-4f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/768fcc0560e8/er-1-2-57-4f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/06c8837b763d/er-1-2-57-4f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/5fb338b4a221/er-1-2-57-4f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/b8ebff2b8f2e/er-1-2-57-4f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/a2c62d45d349/er-1-2-57-4f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/68f79a6e73f2/er-1-2-57-4f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/768fcc0560e8/er-1-2-57-4f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbb/3952333/06c8837b763d/er-1-2-57-4f6.jpg

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3
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4
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5
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