Romantsov M G, Lysenko I M, Mel'nikova I Iu
Eksp Klin Farmakol. 2014;77(1):38-42.
Interferon is the most important mediator of natural immunity, which suggests the use of interferon inducers as therapeutic and preventive agents in the treatment of acute respiratory diseases (ARDs) in children classified into a group of sickly and repeated-ARD patients. The article describes cycloferon--a drug belonging to the group of endogenous interferon inductor--and its mechanism of action, shows its prophylactic and therapeutic efficacy in children with recurrent ARDs. The clinical and pharmacological effectiveness of cycloferon has been confirmed by studying the proteomic profiles of blood plasma in sickly children.
干扰素是天然免疫最重要的介质，这表明在治疗分类为体弱和反复患急性呼吸道疾病（ARDs）的儿童急性呼吸道疾病时，可使用干扰素诱导剂作为治疗和预防药物。本文描述了环磷酰胺——一种属于内源性干扰素诱导剂类别的药物——及其作用机制，展示了其在复发性ARDs儿童中的预防和治疗效果。通过研究体弱儿童血浆的蛋白质组学图谱，证实了环磷酰胺的临床和药理有效性。
