Mamaev N, Zhuravlev A, Zhorno L, Neischtadt E
Department of Clinical Cytogenetics, 1st Leningrad Medical Institute.
Arch Geschwulstforsch. 1988;58(6):379-86.
The first detailed description of morphofunctional characteristics of silver-stained nucleoli of tumor cells in a patient with dimorphous pulmonary carcinoma is presented. The article deals with the problems of heterogeneity of tumor cells in respect to nucleolus apparatus. Possible mechanisms that underlie the enlargement of nucleoli of tumor cells and activation of their ribosomal DNA are discussed.
本文首次详细描述了一例双相型肺癌患者肿瘤细胞银染核仁的形态功能特征。文章探讨了肿瘤细胞在核仁结构方面的异质性问题。讨论了肿瘤细胞核仁增大及其核糖体DNA激活的潜在机制。