Gottwald L, Pasz-Walczak G, Piekarski J, Szwalski J, Kubiak R, Spych M, Suzin J, Tyliński W, Sęk P, Jeziorski A
Department of Radiotherapy, Medical University of Lodz , Lodz , Poland.
J Obstet Gynaecol. 2014 May;34(4):346-9. doi: 10.3109/01443615.2014.889667. Epub 2014 Mar 20.
We aimed to evaluate the membrane expression of DcR1 and DcR2 in the normal endometrium (NE), endometrial atypical hyperplasia (EAH) and endometrioid endometrial cancer (EEC). The study comprised 101 patients: 20 NE, 14 EAH and 67 EEC. Membrane expression of DcR1 and DcR2 was examined and presented as total score (TS). The membrane expression of both DcR1 and DcR2 was more common in EEC than in NE (p < 0.001; p < 0.001). A strong correlation was found between type of endometrial tissue (NE/EAH/EEC) and the TS of DcR1 (p = 0.001) and DcR2 (p < 0.001). In EEC, the TS of DcR1 and DcR2 was not related to grading and survival. The TS of DcR1 negatively correlated with staging (p = 0.018), but DcR2 did not. The membrane expression of decoy receptors for TRAIL DcR1 and DcR2 is greater in NE than EEC. In EEC patients, membrane expression of DcR1 and DcR2 are not independent predictors of survival.
我们旨在评估DcR1和DcR2在正常子宫内膜（NE）、子宫内膜非典型增生（EAH）和子宫内膜样腺癌（EEC）中的膜表达情况。该研究纳入了101例患者：20例NE、14例EAH和67例EEC。检测了DcR1和DcR2的膜表达，并以总分（TS）表示。与NE相比，DcR1和DcR2的膜表达在EEC中更为常见（p < 0.001；p < 0.001）。发现子宫内膜组织类型（NE/EAH/EEC）与DcR1（p = 0.001）和DcR2（p < 0.001）的TS之间存在强相关性。在EEC中，DcR1和DcR2的TS与分级和生存率无关。DcR1的TS与分期呈负相关（p = 0.018），但DcR2并非如此。TRAIL诱饵受体DcR1和DcR2的膜表达在NE中高于EEC。在EEC患者中，DcR1和DcR2的膜表达不是生存的独立预测因素。
