结节性淋巴细胞为主型霍奇金淋巴瘤：生物学、诊断与治疗
Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment.
作者信息
Goel Anupama, Fan Wen, Patel Amit A, Devabhaktuni Madhuri, Grossbard Michael L
机构信息
Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY; Mt Sinai Health System.
Department of Hematology and Oncology, St Luke's Roosevelt Hospital Center, New York, NY; Mt Sinai Health System.
出版信息
Clin Lymphoma Myeloma Leuk. 2014 Aug;14(4):261-70. doi: 10.1016/j.clml.2014.01.006. Epub 2014 Feb 3.
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon variant of classical Hodgkin lymphoma. It is characterized histologically by presence of lymphohistiocytic cells which have B-cell phenotype, are positive for CD19, CD20, CD45, CD79a, BOB.1, Oct.2, and negative for CD15 and CD30. Patients often present with early stage of disease and do not have classical B symptoms. The clinical behavior appears to mimic that of an indolent non-Hodgkin lymphoma more than that of classical Hodgkin disease. The purpose of the present report is to define the biology of NLPHL, review its clinical presentation, and summarize the available clinical data regarding treatment.
结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHL）是经典型霍奇金淋巴瘤的一种罕见变体。其组织学特征为存在具有B细胞表型的淋巴组织细胞，这些细胞CD19、CD20、CD45、CD79a、BOB.1、Oct.2呈阳性，而CD15和CD30呈阴性。患者常表现为疾病早期，且无典型的B症状。其临床行为似乎更类似于惰性非霍奇金淋巴瘤，而非经典型霍奇金病。本报告的目的是明确NLPHL的生物学特性，回顾其临床表现，并总结有关治疗的现有临床数据。
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