Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Cancer Cell. 2014 Mar 17;25(3):265-7. doi: 10.1016/j.ccr.2014.03.002.
Tumors arise from single cells but become genetically heterogeneous through continuous acquisition of somatic mutations as they progress. In this issue of Cancer Cell, Klco and colleagues used whole genome sequence analysis to demonstrate the correlation of genetic clonal architecture with functional heterogeneity in acute myeloid leukemia.
肿瘤起源于单个细胞，但随着肿瘤的进展，通过不断获得体细胞突变，其遗传异质性逐渐增加。在本期 Cancer Cell 杂志上，Klco 及其同事利用全基因组序列分析，证明了急性髓系白血病的遗传克隆结构与功能异质性之间的相关性。
