Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK.
CR-UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Cancer Cell. 2014 Mar 17;25(3):304-17. doi: 10.1016/j.ccr.2014.01.021.
Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.
许多不同类型的癌症都表现出高频率的 TP53 突变，导致突变型 p53 蛋白的表达。越来越多的证据表明，这些突变型 p53 既失去了野生型 p53 的肿瘤抑制活性，又获得了有助于促进恶性进展的功能。了解突变型 p53 的功能将有助于开发新的治疗方法，这些方法可能对广泛的癌症类型都有用。
Zotero 插件