The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
In the past fifteen years, it has become apparent that tumour-associated p53 mutations can provoke activities that are different to those resulting from simply loss of wild-type tumour-suppressing p53 function. Many of these mutant p53 proteins acquire oncogenic properties that enable them to promote invasion, metastasis, proliferation and cell survival. Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions.
在过去的十五年中，人们已经明显认识到，肿瘤相关的 p53 突变可以引发不同于单纯丧失野生型肿瘤抑制 p53 功能的作用。许多这些突变 p53 蛋白获得致癌特性，使它们能够促进侵袭、转移、增殖和细胞存活。在这里，我们强调了一些新兴的分子机制，通过这些机制，突变 p53 蛋白可以发挥这些致癌功能。
