Iafrancesco Mauro, Ranasinghe Aaron M, Claridge Martin W, Mascaro Jorge G, Adam Donald J
Department of Cardiothoracic Surgery/Thoracic Aortic Multidisciplinary Team, Queen Elizabeth University Hospital NHS Foundation Trust, Birmingham, UK Vascular Surgery Department/Thoracic Aortic Multidisciplinary Team, Heart of England NHS Foundation Trust, Birmingham, UK
Department of Cardiothoracic Surgery/Thoracic Aortic Multidisciplinary Team, Queen Elizabeth University Hospital NHS Foundation Trust, Birmingham, UK.
Eur J Cardiothorac Surg. 2014 Dec;46(6):981-4; discussion 984. doi: 10.1093/ejcts/ezu090. Epub 2014 Mar 20.
Fenestrated and branch endografts represent a totally endovascular solution for high-risk patients with atherosclerotic thoraco-abdominal aortic aneurysms (TAAAs). This study reports the early outcome of endovascular TAAA repair.
Interrogation of a prospective database of consecutive patients who underwent endovascular repair (EVAR) for TAAA between June 2007 and October 2012.
Sixty-two high-risk patients (55 men; median age 72, range 54-84 years) underwent fenestrated (n = 39) or branch (n = 23) EVAR for non-ruptured TAAA [extent I-III (n = 26) and IV (n = 36)]. Twenty patients had undergone 22 previous aortic procedures. A total of 221 target vessels (coeliac 50, superior mesenteric 61, renal 106, left subclavian 1 and hypogastric 3) were preserved with scallops (n = 17), fenestrations (n = 140) or branches (n = 62) and 201 of these vessels were stent-grafted (coeliac 34, superior mesenteric 58, renal 105, left subclavian 1 and hypogastric 3). The 30-day mortality was 1.6% (n = 1) and one further patient died on postoperative day 62 from respiratory complications. Spinal cord injury (SCI) developed in 5 (8%) patients (3 women and 2 men). Two patients required temporary renal replacement therapy and a further two commenced planned postoperative dialysis.
In high-risk patients with TAAA, fenestrated and branch EVAR is associated with low early mortality and requirement for renal support, but the risk of SCI is not insignificant despite the use of cerebrospinal fluid drainage and blood pressure manipulation. Our current practice is to stage the repair of extent I-III aneurysms and this has significantly reduced the incidence of SCI.
开窗和分支型腔内移植物为患有动脉粥样硬化性胸腹主动脉瘤(TAAA)的高危患者提供了一种完全腔内治疗方案。本研究报告了腔内TAAA修复的早期结果。
对2007年6月至2012年10月期间连续接受TAAA腔内修复(EVAR)的患者的前瞻性数据库进行查询。
62例高危患者(55例男性;中位年龄72岁,范围54 - 84岁)接受了开窗(n = 39)或分支(n = 23)EVAR治疗非破裂性TAAA [I - III型(n = 26)和IV型(n = 36)]。20例患者此前接受过22次主动脉手术。总共221条靶血管(腹腔干50条、肠系膜上动脉61条、肾动脉106条、左锁骨下动脉1条和髂内动脉3条)通过扇贝型(n = 17)、开窗(n = 140)或分支(n = 62)得以保留,并对其中201条血管进行了支架植入(腹腔干34条、肠系膜上动脉58条、肾动脉105条、左锁骨下动脉1条和髂内动脉3条)。30天死亡率为1.6%(n = 1),另有1例患者在术后第62天因呼吸并发症死亡。5例(8%)患者发生脊髓损伤(SCI)(3例女性和2例男性)。2例患者需要临时肾脏替代治疗,另有2例开始计划中的术后透析。
在患有TAAA的高危患者中,开窗和分支型EVAR与较低的早期死亡率及肾脏支持需求相关,但尽管采用了脑脊液引流和血压调控措施,SCI风险仍不容小觑。我们目前的做法是分期修复I - III型动脉瘤,这显著降低了SCI的发生率。