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奥曲肽治疗非小细胞肺癌相关的疼痛性肥大性骨关节病:一例报告并文献复习

Treatment of painful hypertrophic osteoarthropathy associated with non-small cell lung cancer with octreotide: a case report and review of the literature.

作者信息

Birch Elizabeth, Jenkins Debbie, Noble Simon

机构信息

Department of Palliative Medicine, Royal Gwent Hospital, Newport, UK.

出版信息

BMJ Support Palliat Care. 2011 Sep;1(2):189-92. doi: 10.1136/bmjspcare-2011-000052. Epub 2011 Aug 9.

Abstract

Hypertrophic osteoarthropathy (HOA) is a syndrome most commonly associated with non-small cell lung cancer and consists of periostitis, digital clubbing and painful polyarthropathy. Its symptoms may be disabling and are reportedly difficult to manage effectively with conventional analgesia. We present a case of a lung cancer patient with opioid resistant painful HOA in whom analgesia was achieved with octreotide.

摘要

肥厚性骨关节病(HOA)是一种最常与非小细胞肺癌相关的综合征,由骨膜炎、杵状指和疼痛性多关节病组成。其症状可能会使人丧失活动能力,据报道,传统镇痛方法难以有效控制这些症状。我们报告一例肺癌患者,其患有对阿片类药物耐药的疼痛性HOA,使用奥曲肽实现了镇痛。

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