Maroli Sohani, Srinath H P, Goinka Chanchal, Yadav Naveen S, Bhardwaj Archana, Varghese Rana K
Department of Conservative Dentistry & Endodontics, St. Joseph Dental College, Duggirala, Andhra Pradesh, India.
Department of Prosthodontics, St. Joseph Dental College, Duggirala, Andhra Pradesh, India.
J Int Oral Health. 2014 Feb;6(1):66-71. Epub 2014 Feb 26.
Orofacial pain is a common encounter in dentistry (affecting 12% of the population) and is a primary reason for patients seeking emergency care. Dentists often prescribe oral analgesics, which have disadvantages of decreased absorption rates and delayed onset. Intranasal (IN) delivery takes advantage of a large surface area of mucosal tissue for rapid absorption. The purpose of this study was to evaluate the efficacy of IN ketorolac for endodontic pain using a randomized, double-blind, placebocontrolled parallel design study.
MATERIALS & METHODS: Twenty patients presenting with moderate to severe endodontic pain were selected to receive IN treatment with placebo (n = 10) or ketorolac (n = 10) 30 minutes before endodontic treatment was started and immediately after the completion of endodontic treatment. Baseline pain levels were recorded before IN treatment. Pain levels were also recorded at 15 and 30 minutes after the initial IN dosing (before endodontic treatment); 30 minutes after completion of endodontic treatment; and 4, 8, and 12 hours after the initial IN spray.
IN ketorolac alone or with endodontic treatment showed significantly better pain relief compared with IN placebo spray alone or with endodontic treatment at 30 minutes after the first or second intranasal dose and at 4 hours after the first intranasal dose.
These results suggest that IN ketorolac may provide a novel and efficacious method for pain relief in endodontic pain patients. How to cite the article: Maroli S, Srinath HP, Goinka C, Yadav NS, Bhardwaj A, Varghese RK. Sniffing out pain: An in vivo intranasal study of analgesic efficacy. J Int Oral Health 2014;6(1):66-71.
口面部疼痛在牙科领域较为常见（影响12%的人群），是患者寻求急诊治疗的主要原因。牙医通常会开具口服镇痛药，但这类药物存在吸收率降低和起效延迟的缺点。鼻内给药利用了黏膜组织的大表面积来实现快速吸收。本研究的目的是采用随机、双盲、安慰剂对照平行设计研究，评估鼻内给予酮咯酸治疗牙髓疼痛的疗效。
选取20例中度至重度牙髓疼痛患者，在牙髓治疗开始前30分钟和牙髓治疗完成后立即给予安慰剂（n = 10）或酮咯酸（n = 10）进行鼻内治疗。在鼻内治疗前记录基线疼痛水平。在首次鼻内给药后15分钟和30分钟（牙髓治疗前）、牙髓治疗完成后30分钟以及首次鼻内喷雾后4、8和12小时也记录疼痛水平。
在首次或第二次鼻内给药后30分钟以及首次鼻内给药后4小时，单独使用鼻内酮咯酸或联合牙髓治疗相比单独使用鼻内安慰剂喷雾或联合牙髓治疗，疼痛缓解效果显著更好。
这些结果表明，鼻内给予酮咯酸可能为牙髓疼痛患者提供一种新的有效止痛方法。如何引用本文：Maroli S, Srinath HP, Goinka C, Yadav NS, Bhardwaj A, Varghese RK. Sniffing out pain: An in vivo intranasal study of analgesic efficacy. J Int Oral Health 20
