Yang H L, Liu F C, Tsai S C, Tsay P K, Lin H T, Liu H E
Department of Nursing, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Biomed Res Int. 2016;2016:4582439. doi: 10.1155/2016/4582439. Epub 2016 Nov 29.
. Postoperative sore throat is one of the major complaints of general anesthesia in the postanesthesia care unit. This prospective study investigated the preventive effect of ketorolac tromethamine spray in postendotracheal-intubation-induced sore throat after general anesthesia. . Surgical patients undergoing general anesthesia with endotracheal intubation were recruited from a medical center. Patients were randomly assigned to group K (treated with 5% ketorolac tromethamine spray) or group D (treated with distilled water spray). Before intubation, each endotracheal tube was sprayed with the appropriate solution by physicians over the 20 cm length of the cuff. Each group comprised 95 patients fitting the inclusion and exclusion criteria for whom complete data sets were collected. The intensity of the sore throat was measured at 1, 3, 6, and 24 h after surgery, and data were compared. . The two groups had similar characteristics. Postoperative sore throat was significantly less frequent in group K than in group D ( < 0.001) and the pain intensity was significantly lower in group K than in group D at each time point (all < 0.001). . This study demonstrated that preanesthesia 5% ketorolac tromethamine spray could effectively decrease postendotracheal-intubation-induced sore throat in patients undergoing general anesthesia.
术后咽痛是麻醉后护理单元全身麻醉的主要主诉之一。这项前瞻性研究调查了酮咯酸氨丁三醇喷雾剂对全身麻醉后气管插管引起的咽痛的预防效果。从一家医疗中心招募接受全身麻醉并气管插管的手术患者。患者被随机分为K组（用5%酮咯酸氨丁三醇喷雾剂治疗）或D组（用蒸馏水喷雾剂治疗）。插管前，医生在气管导管套囊20厘米长度范围内喷洒相应溶液。每组包括95例符合纳入和排除标准且收集了完整数据集的患者。在术后1、3、6和24小时测量咽痛强度，并对数据进行比较。两组具有相似的特征。K组术后咽痛的发生率明显低于D组（<0.001），且在每个时间点K组的疼痛强度均明显低于D组（均<0.001）。这项研究表明，麻醉前使用5%酮咯酸氨丁三醇喷雾剂可有效减轻全身麻醉患者气管插管后引起的咽痛。
