Denburg J L, Powell S L, Murphy B F
Biology Department, University of Iowa, Iowa City 52242.
J Neurobiol. 1988 Oct;19(7):656-65. doi: 10.1002/neu.480190707.
Competition among axon terminals is usually considered to contribute to the formation of patterned synaptic connections. During axonal regeneration of motor neurons in the cockroach, leg muscles initially become innervated by appropriate and inappropriate motor neurons. All axon terminals from inappropriate neurons eventually are eliminated, resulting in the reformation of the original innervation pattern. Destruction of an identified motor neuron by the intracellular injection of pronase did not prevent the elimination of inappropriate axon terminals in the muscle normally innervated by that motor neuron. Therefore, competition does not play a role in the reinnervation of the leg muscles. This indicates a major role for specific cell-cell recognition.
轴突末端之间的竞争通常被认为有助于形成有模式的突触连接。在蟑螂运动神经元的轴突再生过程中，腿部肌肉最初会被合适和不合适的运动神经元支配。来自不合适神经元的所有轴突末端最终都会被清除，从而导致原始支配模式的重新形成。通过细胞内注射链霉蛋白酶破坏一个已识别的运动神经元，并不能阻止在该运动神经元正常支配的肌肉中不合适轴突末端的清除。因此，竞争在腿部肌肉的重新支配中不起作用。这表明特定细胞间识别起主要作用。
