Marin F, Pleşca M, Bordea C I, Voinea S C, Burlănescu I, Ichim E, Jianu C G, Nicolăescu R R, Teodosie M P, Maher K, Blidaru A
Department of Surgical Oncology II, " Prof. Dr. Al Trestioreanu " Institute of Oncology, Bucharest.
J Med Life. 2014 Mar 15;7(1):60-6. Epub 2014 Mar 25.
Rationale The current standard surgical treatment for the cervix and uterine cancer is the radical hysterectomy (lymphadenohysterocolpectomy). This has the risk of intraoperative accidents and postoperative associated morbidity. Objective The purpose of this article is the evaluation and quantification of the associated complications in comparison to the postoperative morbidity which resulted after different types of radical hysterectomy. METHODS AND RESULTS PATIENTS WERE DIVIDED ACCORDING TO THE TYPE OF SURGERY PERFORMED AS FOLLOWS: for cervical cancer - group A- 37 classic radical hysterectomies Class III Piver - Rutledge -Smith ( PRS ), group B -208 modified radical hysterectomies Class II PRS and for uterine cancer- group C -79 extended hysterectomies with pelvic lymphadenectomy from which 17 patients with paraaortic lymphnode biopsy . All patients performed preoperative radiotherapy and 88 of them associated radiosensitization. Discussion Early complications were intra-abdominal bleeding ( 2.7% Class III PRS vs 0.48% Class II PRS), supra-aponeurotic hematoma ( 5.4% III vs 2.4% II) , dynamic ileus (2.7% III vs 0.96% II) and uro - genital fistulas (5.4% III vs 0.96% II).The late complications were the bladder dysfunction (21.6% III vs 16.35% II) , lower limb lymphedema (13.5% III vs 11.5% II), urethral strictures (10.8% III vs 4.8% II) , incisional hernias ( 8.1% III vs 7.2% II), persistent pelvic pain (18.91% III vs 7.7% II), bowel obstruction (5.4% III vs 1.4% II) and deterioration of sexual function (83.3% III vs 53.8% II). PRS class II radical hysterectomy is associated with fewer complications than PRS class III radical hysterectomy , except for the complications of lymphadenectomy . A new method that might reduce these complications is a selective lymphadenectomy represented by sentinel node biopsy . In conclusion PRS class II radical hysterectomy associated with neoadjuvant radiotherapy is a therapeutic option for the incipient stages of cervical cancer.
PRS- Piver Rutledge-Smith, II- class II, III- class III.
理论依据 目前宫颈癌和子宫癌的标准外科治疗方法是根治性子宫切除术(淋巴结清扫子宫切除术)。这存在术中意外和术后相关并发症的风险。目的 本文旨在评估和量化与不同类型根治性子宫切除术后的术后发病率相比的相关并发症。方法与结果 根据所进行的手术类型将患者分为以下几组:对于宫颈癌——A组——37例III级皮弗-拉特利奇-史密斯(PRS)经典根治性子宫切除术,B组——208例II级PRS改良根治性子宫切除术;对于子宫癌——C组——79例行盆腔淋巴结清扫的扩大子宫切除术,其中17例患者进行了腹主动脉旁淋巴结活检。所有患者均接受了术前放疗,其中88例联合了放射增敏治疗。讨论 早期并发症包括腹腔内出血(III级PRS为2.7%,II级PRS为0.48%)、腱膜上血肿(III级为5.4%,II级为2.4%)、动力性肠梗阻(III级为2.7%,II级为0.96%)和泌尿生殖瘘(III级为5.4%,II级为0.96%)。晚期并发症包括膀胱功能障碍(III级为21.6%,II级为16.35%)、下肢淋巴水肿(III级为13.5%,II级为11.5%)、尿道狭窄(III级为10.8%,II级为4.8%)、切口疝(III级为8.1%,II级为7.2%)、持续性盆腔疼痛(III级为18.91%,II级为7.7%)、肠梗阻(III级为5.4%,II级为1.4%)和性功能减退(III级为83.3%,II级为53.8%)。II级PRS根治性子宫切除术比III级PRS根治性子宫切除术的并发症少,除了淋巴结清扫的并发症。一种可能减少这些并发症的新方法是以前哨淋巴结活检为代表的选择性淋巴结清扫。总之,II级PRS根治性子宫切除术联合新辅助放疗是宫颈癌早期阶段的一种治疗选择。
PRS - 皮弗-拉特利奇-史密斯,II - II级,III - III级