异氟烷对小鼠听力的影响。
Effect of isoflurane on the hearing in mice.
作者信息
Kim Joung Uk, Ahn Yun Suk, Suh Jin Kyung, Chung Jong Woo
机构信息
Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
出版信息
Korean J Audiol. 2012 Apr;16(1):14-7. doi: 10.7874/kja.2012.16.1.14. Epub 2012 Apr 30.
BACKGROUND AND OBJECTIVES
The aim of this study was to investigate the relationship between inhalation anesthetics and hearing in mice.
MATERIALS AND METHODS
As inhalation anesthetics, isoflurane was used. Auditory brainstem response and distortion product otoacoustic emission were used as measurement of hearing. Mice were divided into 2 groups. 'Isoflurane group' consisted of mice that were anesthetized with an inspired concentration of 2.0 vol% isoflurane with 2 L/min of oxygen (n=10). 'Control group' consisted of mice that were anesthetized with ketamine and xylazine (n=10).
RESULTS
Auditory brainstem response thresholds in mice anesthetized with ketamine and xylazine was not different from those in mice anesthetized with isoflurane. Threshold of DPOAE was higher in mice with isolurane than with ketamine and xylazine. Changes of efferent control may be induced by isoflurane and consequently change the threshold of DPOAE in mice.
CONCLUSIONS
These results infer that, there was a change of central nervous system induced by inhalation anesthetics, this change also can be applied to the strategies for prevention of hearing loss.
背景与目的
本研究旨在探讨吸入麻醉剂与小鼠听力之间的关系。
材料与方法
使用异氟烷作为吸入麻醉剂。采用听性脑干反应和畸变产物耳声发射作为听力测量指标。将小鼠分为2组。“异氟烷组”由吸入浓度为2.0体积%异氟烷和2升/分钟氧气麻醉的小鼠组成（n = 10）。“对照组”由用氯胺酮和赛拉嗪麻醉的小鼠组成（n = 10）。
结果
用氯胺酮和赛拉嗪麻醉的小鼠听性脑干反应阈值与用异氟烷麻醉的小鼠无差异。异氟烷麻醉的小鼠畸变产物耳声发射阈值高于氯胺酮和赛拉嗪麻醉的小鼠。异氟烷可能诱导传出控制的改变，从而改变小鼠畸变产物耳声发射的阈值。
结论
这些结果推断，吸入麻醉剂可引起中枢神经系统的变化，这种变化也可应用于预防听力损失的策略。
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