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从果蝇大脑中的神经遗传学研究到昼夜节律生物学中的一个概念。

From neurogenetic studies in the fly brain to a concept in circadian biology.

作者信息

Helfrich-Förster Charlotte

机构信息

Neurobiology and Genetics, Biocenter, Theodor-Boveri Institute, University of Würzburg , Würzburg , Germany.

出版信息

J Neurogenet. 2014 Sep-Dec;28(3-4):329-47. doi: 10.3109/01677063.2014.905556. Epub 2014 May 7.

DOI:10.3109/01677063.2014.905556
PMID:24655073
Abstract

This paper is dedicated to Karl-Friedrich Fischbach, who has always shared with me the interest in the function of the fly brain, especially that of its optic lobes. He has accompanied me during my first steps in scientific research. The paper tells the story how our first common attempts to localize the circadian clock in the fly brain finally helped in phrasing the two-oscillator principle of circadian clocks that seems to be valid far beyond the fly circadian system. I hope that Karl-Friedrich will take this story as praise for his generosity in supporting younger scientists outside his own lab, even without the reward of a common paper.

摘要

本文献给卡尔 - 弗里德里希·菲施巴赫,他一直与我共同对果蝇大脑的功能,尤其是其视叶的功能有着浓厚兴趣。在我科研生涯的起步阶段,他一直陪伴着我。本文讲述了我们最初共同尝试在果蝇大脑中定位生物钟的经历,这些尝试最终促成了生物钟双振荡器原理的形成,而这一原理似乎在果蝇生物钟系统之外也广泛适用。我希望卡尔 - 弗里德里希会把这个故事视为对他慷慨支持实验室之外年轻科学家的一种赞誉,即便没有共同发表论文的回报。

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