氯氮平治疗迟发性综合征：病例系列

Management of tardive syndromes with clozapine: a case series.

作者信息

Grover Sandeep, Hazari Nandita, Kate Natasha, Chakraborty Kaustav, Sharma Akhilesh, Singh Dharmendra, Gupta Jyoti, Lahariya Sanjay

机构信息

Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

出版信息

Asian J Psychiatr. 2014 Apr;8:111-4. doi: 10.1016/j.ajp.2013.12.016. Epub 2014 Jan 8.

DOI:10.1016/j.ajp.2013.12.016

PMID:24655641

Abstract

Tardive syndromes are among the most debilitating side effects associated with use of antipsychotics. In this case series we present 5 cases of drug induced tardive syndromes, who had not responded to many of the other therapeutic measures but responded to clozapine. The response rate with clozapine varied from 50% to 100% and the response was seen by week 3 in most cases. Over the long term follow-up of as long as 6 years the response to clozapine was sustained. In two cases clozapine could be stopped.

摘要

迟发性综合征是使用抗精神病药物相关的最使人衰弱的副作用之一。在本病例系列中，我们呈现了5例药物诱发的迟发性综合征患者，他们对许多其他治疗措施均无反应，但对氯氮平有反应。氯氮平的有效率从50%到100%不等，大多数情况下在第3周可见疗效。在长达6年的长期随访中，对氯氮平的反应持续存在。有2例患者停用了氯氮平。