Tekin Mehmet, Toplu Yuksel, Kahramaner Zelal, Erdemir Aydin, Gulyuz Abdulgani, Konca Capan, Uckardes Fatih
Adiyaman University, School of Medicine, Department of Pediatrics, Adiyaman, Turkey.
Inonu University, Medical Faculty, Department of Otorhinolaryngology, Malatya, Turkey.
Int J Pediatr Otorhinolaryngol. 2014 May;78(5):850-3. doi: 10.1016/j.ijporl.2014.02.027. Epub 2014 Mar 12.
To assess whether mean platelet volume (MPV) can be used as a marker in the differential diagnosis of periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome.
The leucocyte counts, thrombocyte counts, and MPV values of 57 children with PFAPA syndrome were recorded during an attack and an attack free period. These values were compared with a healthy control group of 55 individuals. Demographic features of the PFAPA patients group including age, gender and age of first attack, age at diagnosis, frequency of attacks, serum reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were also recorded.
The MPV values of the children with PFAPA both during an attack and attack free period were found significantly lower than the MPV values of healthy control group (p<0.001). Also, the MPV values of the children with PFAPA during an attack were significantly lower than in attack free periods (p<0.001). The MPV values showed no correlation with leucocytes counts, CRP, and ESR during attacks. A 8.30fl [area under the curve (AUC: 0.965)] optimal cutoff value of MPV with a sensitivity of 89.5% and specificity of 92.8% was determined during an attack in children with PFAPA.
The MPV values during an attack and attack free period of patients with PFAPA is lower than in controls. The MPV values may be used as a marker in the differential diagnosis of PFAPA syndrome but more studies are needed and they should be prospective in order to validate this data.
评估平均血小板体积（MPV）能否作为周期性发热、口疮性口炎、咽炎、腺炎（PFAPA）综合征鉴别诊断的标志物。
记录57例PFAPA综合征患儿发作期和发作间期的白细胞计数、血小板计数及MPV值。将这些值与55名健康对照组个体进行比较。还记录了PFAPA患者组的人口统计学特征，包括年龄、性别、首次发作年龄、诊断年龄、发作频率、血清反应蛋白（CRP）和红细胞沉降率（ESR）。
发现PFAPA患儿发作期和发作间期的MPV值均显著低于健康对照组（p<0.001）。此外，PFAPA患儿发作期的MPV值显著低于发作间期（p<0.001）。发作期间，MPV值与白细胞计数、CRP和ESR均无相关性。确定PFAPA患儿发作期MPV的最佳截断值为8.30fl[曲线下面积（AUC：0.965）]，敏感性为89.5%，特异性为92.8%。
PFAPA患者发作期和发作间期的MPV值低于对照组。MPV值可作为PFAPA综合征鉴别诊断的标志物，但需要更多的研究，且应为前瞻性研究以验证该数据。
