Cancer Registry of Norway, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway; Department of Genetic Epidemiology, Folkhälsan Research Center, Helsinki, Finland.
Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels, Belgium.
Eur J Cancer. 2014 Jun;50(9):1675-84. doi: 10.1016/j.ejca.2014.02.020. Epub 2014 Mar 20.
The burden of corpus uteri cancer varies in the European Union (EU). We analysed trends in corpus uteri cancer mortality in 26 EU member states from 1970 onward.
Population numbers and number of uterine cancer deaths were extracted from the World Health Organisation mortality database. Corpus uteri cancer mortality rates were corrected for certification problems using different reallocation rules for deaths registered as uterine cancer not otherwise specified, or using mixed disease codes. Join point regression was used to study the annual percentage change of age-standardised corpus uteri cancer mortality rates. Changes in corpus uteri cancer mortality rates by calendar period and standardised cohort mortality ratios were also estimated.
In 2008, 12,903 women died from corpus uteri cancer in the EU. Corrected age-standardised corpus uteri cancer mortality rates have decreased significantly over the past decades in most member states, with exception of Malta and Bulgaria, where rates increased; Greece, where rates remained low but stable; and Sweden, where rates have been stable since 1970. Original member states showed a steeper decrease than newer member states. The standardised cohort mortality ratios indicated that corpus uteri cancer mortality does not decrease further, nor does it increase, among women born after 1940, although these birth cohorts may still be too young for corpus uteri cancer incidence to be fully evaluated.
Our corrected corpus uteri cancer mortality rates showed a decrease in most EU member states among women born before 1940.
欧洲联盟（欧盟）的子宫体癌负担存在差异。我们分析了 1970 年以来 26 个欧盟成员国的子宫体癌死亡率趋势。
从世界卫生组织死亡率数据库中提取了人口数量和子宫癌死亡人数。使用不同的重新分配规则，针对被登记为非特指性子宫癌的死亡病例，或者使用混合疾病编码，对子宫体癌死亡率进行了校正，以纠正认证问题。使用连接点回归分析了年龄标准化子宫体癌死亡率的年百分比变化。还根据日历期和标准化队列死亡率比，估计了子宫体癌死亡率的变化。
2008 年，欧盟有 12903 名妇女死于子宫体癌。在过去几十年中，大多数成员国的校正年龄标准化子宫体癌死亡率都显著下降，只有马耳他和保加利亚的死亡率上升，希腊的死亡率保持在较低水平且稳定，以及瑞典的死亡率自 1970 年以来保持稳定。原始成员国的下降幅度大于新成员国。标准化队列死亡率比表明，1940 年后出生的妇女的子宫体癌死亡率没有进一步下降，也没有上升，尽管这些出生队列可能还太年轻，无法全面评估子宫体癌的发病率。
我们校正后的子宫体癌死亡率显示，在 1940 年前出生的大多数欧盟成员国的妇女中，死亡率呈下降趋势。
